PDF Genetic and molecular alterations in aldosterone

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Centrifuge, separate and send 1.5 mL plasma frozen in a screw-capped plastic vial. CRITICAL FROZEN. Label this tube “Frozen Plasma-Renin”. A high ratio of serum aldosterone (SA) in ng/dL to plasma renin activity (PRA) in ng/mL per hour, is a positive screening test result, a finding that warrants further testing.

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Encourage liberal sodium intake 3. Where possible discontinue medications which significantly affect the ARR: a. 2020-09-08 · Aldosterone-to-renin ratio. The aldosterone-to-renin ratio (ARR)—that is, the ratio of plasma aldosterone (expressed in ng/dL) to plasma renin activity (PRA, expressed in ng/mL/h)—is the most sensitive means of differentiating primary from secondary causes of hyperaldosteronism.

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Centrifuge, separate and send 1.5 mL plasma frozen in a screw-capped plastic vial. CRITICAL FROZEN. Label this tube “Frozen Plasma-Renin”. A high ratio of serum aldosterone (SA) in ng/dL to plasma renin activity (PRA) in ng/mL per hour, is a positive screening test result, a finding that warrants further testing. A SA:PRA ratio > or =20 and SA of > or =15 ng/dL indicates probable primary aldosteronism. Interpretation depends on renin status.

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Renin activates Angiotensin by cleaving Angiotensinogen to release Angiotensin I which through the action of Angiotensin converting enzyme (ACE) produces Angiotensin II. In turn, Angiotensin II, Aldosterone and Na/K ratio including the calculation of Aldo/Renin ratio.

Interpretation depends on renin status. Plasma Aldosterone-Renin ratio greatly assists in diagnosis. High plasma aldosterone levels occur in primary aldosteronism, where the aldosterone/PRA ratio is > 30.5 (pmol/L)/(mIU/L) (Adult) using Endolab methods.
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Interpretation depends on renin status. Plasma Aldosterone-Renin ratio greatly assists in diagnosis.